Nephrology, Urology and Kidney Transplantation

Glomerular-Tubulointerstitial Disorders

Abnormal glomerular function may leads to damage of glomerulus components such as capillary endothelium, mesangium and epithelium basement membrane. In renal biopsy we can see cellular and structural pattern of glomeruli injury by using electron microscopy, light microscopy.

The compartment of tubulointerstitial is damaged in all the forms of kidney disease. As per the time of examination and the intensity of the lesions, in vascular diseases and glomerular we can identify tubular damage in glomerular, interstitial inflammation, tubular atrophy, fibrosis or edema. Tubular or acute interstitial damage can lead acute kidney failure, and prolonged changes are a best investigation of irreversible lesions and then they are great anticipation variables in vascular /glomerular diseases.