Hoda EL-Attar
University of Alexandria, Egypt
Title: Serum levels profile of pentraxin-3 and high sensitivity c-reactive protein in patients with chronic kidney disease treated with or without hemodialysis
Biography
Biography: Hoda EL-Attar
Abstract
Background:
The first cloned long pentraxin is Pentraxin 3(PTX3) and C-reactive protein is a human short pentraxin. Pentraxin 3 has a bigger molecular size (40.6 KDa) compared to CRP (21.5 KDa).The long PTX3 is produced by diverse cell types in response to primary inflammatory signals and specific neutrophil granules store PTX3 .
Aim:
Evaluation of serum levels of long Pentraxin 3 and high sensitivity C-reactive protein in patients with chronic kidney disease treated with or without haemodialysis.
The study included 75 subjects,25 heathy controls(group1),50 patients without cardiovascular disease subdivided into:25 patients with chronic kidney disease (CKD) on conservative therapy(group 2a) and 25CKD patients on maintenance hemodialysis (group2b).To all studied subjects the following was done :electocardiography,carotid intima media thickness, fasting serum glucose ,renal, liver and lipid profiles,high- sensitivity C-reactive protein (hsCRP) and PTX3by ELISA.