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Małgorzata Karbowska

Medical University of Bialystok, Poland

Title: Indoxyl sulfate modulates the activity of coagulation system and fibrinolysis in animal model of experimental arterial thrombosis

Biography

Biography: Małgorzata Karbowska

Abstract

Objective: Chronic kidney disease (CKD) is associated with higher risk for thromboembolic events compared with general population. Indoxyl sulfate (IS) is a potent uremic toxin associated with the appearance of cardiovascular disease prevalence. However, mechanism underlying IS association with thromboembolic events is not fully understood.

Material and methods: We evaluated the effect of IS on thrombotic process after acute treatment in electrical current-induced arterial thrombosis in Wistar male rats. IS doses: 3, 10, and 30 mg/kg of body weight were administered intravenously. We assessed IS influence on parameters of coagulation, fibrinolysis, collagen-induced platelet aggregation and blood morphology.