Tomasz Kamiński
Medical University of Bialystok, Poland
Title: Indoxyl sulfate – a new link between chronic kidney disease and coagulation disorders in CKD patients on conservative treatment.
Biography
Biography: Tomasz Kamiński
Abstract
Objectives: Patients with chronic kidney disease (CKD) are at higher risk of incidence of thromboembolic events. The effect of continuous loss of function of nephrons is a progressive accumulation of uremic toxins. Indoxyl sulfate (IS) is an aggressive uremic toxin exerting proinflammatory and prooxidative properties, which affects multiple signaling pathways.
Aim: We examined the association between indoxyl sulfate and activation of the coagulation system in predialysis patients with CKD.
Methods: Studies have been conducted on a group of 53 patients with CKD on conservative treatment and 18 healthy volunteers. For the determination of parameters of coagulation ELISA-immuno-enzymatic kits were used, whereas the IS levels were determined by HPLC. The hematological and biochemical parameters were assessed using standard laboratory methods.